TET 830 modified/T-helper epitope from tetanus toxoid - AQYIKANSKFIGITEL

TET 830 modified/T-helper epitope from tetanus toxoid – AQYIKANSKFIGITEL Tetanus Tetanus is a life-threatening condition caused by Clostridium tetani bacteria. After entering the body through a break in the skin, they produce a toxin that causes convulsions and severe muscle spasms, that can be strong enough to fracture bones of the spin. Tetanus toxin inhibits neurotransmitter release by binding to peripheral neuronal synapses. The substance will then be internalized and transported to the spinal cord where it will be able to move between postsynaptic and presynaptic neurons. For the time being, there is no cure for tetanus. Indeed, the extreme potency of the tetanospasmin toxin prevents immunity in infected people, leading to 30-40% deaths among this population. Symptoms usually start 4 to 21 days after infection, and most of the people get them after about 10 days. Tetanus vaccine Thanks to the widespread use of tetanus vaccines, infections are rare in many countries. However, this disease remains a threat for people without access to vaccination. Immunization against tetanus is recommended for all infants between 6 and 8, all children, and all adults. Immunization is achieved by 3 or 4 injection of tetanus toxoid (inactivated toxin) completed by booster injections every 10 years. Tetanus Toxoid Tetanus toxoid is the altered form of tetanus toxin (UniProt: P04958), used in vaccines to prevent tetanus infection. Tetanus Toxin QYIKANSKFIGITEL peptide explications SB-PEPTIDE Tetanus toxin actes as a zinc endopeptidase, that cleaves the ’76-Gln-|-Phe-77′ bond within synaptobrevin-2, thereby impeding the release of neurotransmitters. AQYIKANSKFIGITEL – Tetanus helper peptide Among the 1315 amino acids composing tetanus toxoid, researchers identified the fragment (830-844) QYIKANSKFIGITEL (see #SB305 – TET 830 peptide) that binds to MHC class II molecules as a nonspecific vaccine adjuvant to induce and increase the helper T-cell response. Later addition of Alanine at the N-terminal of the sequence turned the peptide into a universal human tetanus toxin T-cell epitope that can be used as helper peptide in vaccinations.