SYFPEITHI MHC binding peptide

SYFPEITHI MHC binding peptide SB-PEPTIDE offers SYFPEITHI peptide for immune reactivity studies and MHC ligand assays. Major Histocompatibility Complex (MHC) MHC is a large cluster of genes, called Human Leukocyte Antigens (HLA) in humans and H-2 complex in mice. This DNA locus of highly polymorphic genes codes for MHC molecules, present on the cell surface, whose function is to present antigens to T-cells. Foreign antigen presentation by MHC proteins triggers the appropriate T-cells to proliferate and generate a specific cellular immune response. The polygenism and polymorphism of MHC molecules make it difficult for pathogens to evade immune responses. This complex contains several different MHC class I and MHC class II genes to ensure that each individual has a unique set of MHC molecules capable of binding to a diverse range of peptides. MHC-I proteins are found on all nucleated cells, while MHC-II molecules are restricted to antigen-presenting cells (APCs) . MHC binding peptides Peptides binding MHC molecules play a key role in cell-mediated immunity, as T-cells are only able to recognize foreign antigens when bound to an MHC protein. Antigenic peptide are categorized as endogenous whether they are derived from viruses, intracellular bacteria, or protozoan parasites; or as exogeneous if they originate from pathogens that replicate outside of the cell. In order to trigger adaptive immunity towards a specific condition, peptides able to bind to all kind of MHC molecules are needed. Among these peptides, SYFPEITHI has been tested in multiple MHC ligand assays and its ability to bind both MHC class I and II molecules was demonstrated (see IEDB SYFPEITHI epitope summary) . Tyrosine Kinase (367-375) epitope – SYFPEITHI SYFPEITHI is a linear peptide from Tyrosine-protein kinase JAK1 (UniProt: P23458) in Humans and from Tyrosine-protein kinase (UniProt: B1ASP2) and Tyrosine-protein kinase JAK1 (UniProt: P52332) in mice. Tyrosine kinase is a cellular enzyme catalyzing the transfer of a phosphate group from ATP to a protein, according to the reaction below: ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein] These proteins are important mediators to switch « on » or « off » biological processes, such as cellular growth, differentiation, metabolism and apoptosis, in response to external and internal stimuli. Among tyrosine kinases, Janus kinase 1 (JAK1) is an essential protein interacting with type I and type II cytokines, especially involved in T-cells expansion. Epitope screening of Human and Mouse JAK1, as well as mouse Tyrosine Kinase, highlighted SYFPEITHI peptide as an interesting epitope to induce immune reactivity. The interest for MHC binding peptides stems from the growing importance for T-cells to address various diseases. Moreover, studies showed that SYFPEITHI might be used as Tumor Antigen (TA) in vaccine development to treat cancer. For MHC binding peptides prediction, visit our related webpage to use the most appropriate database.