Nesbuvir

Nesbuvir is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase.

Product Specifications

CAS Number

[691852-58-1]

Product Name Alternative

HCV-796

UNSPSC

12352005

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nesbuvir.html

Concentration

10mM

Purity

99.21

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(C1=C(C2=CC=C(F)C=C2)OC3=CC(N(CCO)S(=O)(C)=O)=C(C4CC4)C=C13)NC

Molecular Formula

C22H23FN2O5S

Molecular Weight

446.49

References & Citations

[1]Flint M, et al. Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034) . Antimicrob Agents Chemother. 2009 Feb;53 (2) :401-11.|[2]Reich S, et al. Mechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem. 2010 Apr 30;285 (18) :13685-93.