Desmoplakin (phospho-Ser165/166) rabbit pAb
This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Product Specifications
Background
This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt
P15924
Swiss Prot
P15924
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized phosho peptide around human Desmoplakin (Ser165 and 166)
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:1000-2000
Molecular Weight
300kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
300kD
Fragment
IgG
Subcellular Location
Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069) . Localizes at the intercalated disk in cardiomyocytes (By similarity) . .
Other Product Names
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene ID (Human)
1832
Available Sizes
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