Desmoplakin (phospho-Ser165/166) rabbit pAb

This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

Product Specifications

Background

UniProt

P15924

Swiss Prot

P15924

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized phosho peptide around human Desmoplakin (Ser165 and 166)

Clonality

Polyclonal

Source

Rabbit

Applications

Concentration

1 mg/ml

Dilution

WB 1:1000-2000

Molecular Weight

300kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

300kD

Fragment

IgG

Subcellular Location

Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069) . Localizes at the intercalated disk in cardiomyocytes (By similarity) . .