PF-06282999

PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.

Product Specifications

CAS Number

[1435467-37-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/PF-06282999.html

Purity

99.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N)CN(C(C1=CC(Cl)=CC=C1OC)=C2)C(NC2=O)=S

Molecular Formula

C13H12ClN3O3S

Molecular Weight

325.77

Precautions

H302, H315, H319, H335

References & Citations

[1]Dong JQ, et al. Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug Metab Dispos. 2016 Feb;44 (2) :209-19.|[2]Ruggeri RB, et al. Discovery of 2- (6- (5-Chloro-2-methoxyphenyl) -4-oxo-2-thioxo-3,4-dihydropyrimidin-1 (2H) -yl) acetamide (PF-06282999) : A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. J Med Chem. 20