PF-06282999
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.
Product Specifications
CAS Number
1435467-37-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/PF-06282999.html
Purity
99.02
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N)CN(C(C1=CC(Cl)=CC=C1OC)=C2)C(NC2=O)=S
Molecular Formula
C13H12ClN3O3S
Molecular Weight
325.77
Precautions
H302, H315, H319, H335
References & Citations
[1]Dong JQ, et al. Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug Metab Dispos. 2016 Feb;44 (2) :209-19.|[2]Ruggeri RB, et al. Discovery of 2- (6- (5-Chloro-2-methoxyphenyl) -4-oxo-2-thioxo-3,4-dihydropyrimidin-1 (2H) -yl) acetamide (PF-06282999) : A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. J Med Chem. 20
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
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