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Nefopam

Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups[1][2][3].

Product Specifications

CAS Number

[13669-70-0]

Product Name Alternative

Fenazoxine

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nefopam.html

Solubility

10 mM in DMSO

Smiles

CN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3C1

Molecular Formula

C17H19NO

Molecular Weight

253.34

References & Citations

[1]Lee JY, et al. The Antiallodynic Effect of Nefopam on Vincristine-Induced Neuropathy in Mice. J Pain Res. 2020 Feb 7;13:323-329. |[2]Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27 (2) :103-11. |[3]Verleye M, et al. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res. 2004 Jul 9;1013 (2) :249-55.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 4

Curated Selection

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