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PARP10-IN-2

PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1].

Product Specifications

CAS Number

[1042780-52-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp10-in-2.html

Purity

98.02

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(C=C1)OC2=CC=C(C(N)=O)C=C2

Molecular Formula

C14H10N2O2

Molecular Weight

238.24

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10 (10) :939-948.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP1; PARP10; PARP12; PARP14; PARP15; PARP16; PARP2; PARP3; PARP4; TNKS1/PARP5A; TNKS2/PARP5B

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