(αR) -Cyclopropaneacetamide-Exatecan
(αR) -Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, is a cytotoxic agent. (αR) -Cyclopropaneacetamide-Exatecan inhibits U87MG and SK-BR-3 cells proliferation, with IC50s of 8.11 and 2.31 μM[1].
Product Specifications
CAS Number
[2414254-37-6]
Product Name Alternative
SHR169265
UNSPSC
12352005
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/αr-cyclopropaneacetamide-exatecan.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H](C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O
Molecular Formula
C29H28FN3O6
Molecular Weight
533.55
References & Citations
[1]Haiqing H, et, al. Antibody-drug conjugate and medical use thereof. WO2021190564A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
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