K-Ras ligand-Linker Conjugate 5
K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP) . K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
Product Specifications
CAS Number
[2378261-85-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k-ras-ligand-linker-conjugate-5.html
Purity
99.79
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C
Molecular Formula
C42H59N7O8
Molecular Weight
789.96
Precautions
H302, H315, H319, H335
References & Citations
[1]CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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