RO0711401

RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM[1][2].

Product Specifications

CAS Number

[714971-87-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ro0711401.html

Purity

98.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC(C(F)(F)F)=CO1)C2C3=C(C=CC=C3)OC4=C2C=CC=C4

Molecular Formula

C18H11F3N2O3

Molecular Weight

360.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Serena Notartomaso, et al. Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1. Mol Brain. 2013 Nov 19;6:48.|[2]Eric Vieira, et al. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2009 Mar 15;19 (6) :1666-9.