RO0711401
RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM[1][2].
Product Specifications
CAS Number
714971-87-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro0711401.html
Purity
98.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(C(F)(F)F)=CO1)C2C3=C(C=CC=C3)OC4=C2C=CC=C4
Molecular Formula
C18H11F3N2O3
Molecular Weight
360.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Serena Notartomaso, et al. Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1. Mol Brain. 2013 Nov 19;6:48.|[2]Eric Vieira, et al. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2009 Mar 15;19 (6) :1666-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1
Available Sizes
Frequently Asked Questions
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