PPQ-102
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM) . PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1].
Product Specifications
CAS Number
[931706-15-9]
Product Name Alternative
CFTR Inhibitor
UNSPSC
12352005
Hazard Statement
H302, H317
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/PPQ-102.html
Purity
99.73
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN1C(C2=C(C3=CC=CC=C3)N4C5=CC=CC=C5NC(C6=CC=C(C)O6)C4=C2N(C)C1=O)=O
Molecular Formula
C26H22N4O3
Molecular Weight
438.48
Precautions
H302, H317
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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