Biotinylated Mouse Podocalyxin Protein, His, Avitag™ (HPLC verified)

Podocalyxin is a heavily glycosylated transmembrane sialoprotein belonging to the CD34 family of cell surface molecules. It is primarily expressed in renal glomerular podocytes, where it plays a critical role in maintaining the integrity of the glomerular filtration barrier through charge-dependent repulsion and modulation of podocyte foot process architecture. The protein’s large extracellular domain, rich in sialic acid residues, mediates interactions with other molecules, influencing cell signaling and migration. Its multifunctional role makes it a potential biomarker and therapeutic target in both renal diseases and cancer research.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) . The protein has a calculated MW of 43.3 kDa. The protein migrates as 95-140 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

Q9R0M4

Expression Region

His 22 - Arg 402

Host

HEK293

Target

Podocalyxin

Conjugation

Biotin-labeled

Tag

C-10xHis & C-Avi

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.