Human PRMT5 & MEP50 Protein, Flag, His Tag (MALS verified)
Protein arginine methyltransferase 5 (PRMT5) is a type II enzyme that catalyzes symmetric dimethylation of arginine residues on histone and non-histone proteins. It forms a hetero-octameric complex with its essential cofactor MEP50 (methylosome protein 50), which enhances its catalytic activity and substrate selectivity. The PRMT5–MEP50 complex regulates gene expression epigenetically, influences RNA splicing, and modulates signal transduction pathways. Aberrant PRMT5–MEP50 activity is linked to tumorigenesis, cardiovascular disorders, and neurodegeneration by driving dysregulated methylation patterns that favor cell proliferation and survival.
Product Specifications
Background
Specifications
Accession Number
O14744-1 & Q9BQA1
Expression Region
Ala 2 - Leu 637 & Arg 2 - Glu 342
Host
Insect Cells
Target
PRMT5 & MEP50
Conjugation
Unconjugated
Tag
N-Flag | N-10xHis
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Purity
90%
Format
Liquid
Buffer
50 mM Tris, 500 mM NaCl, pH7.5
Additives
Glycerol
Molecular Weight
74.4 kDa & 38.3 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
1mg*1
Host or Source
InsectCells
Species
Human
Protein ID
O14744-1 & Q9BQA1
Preservative
Glycerol
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