Human WEE1 Protein, His Tag (active enzyme)
WEE1 is a serine/threonine protein kinase that acts as a critical regulator of the cell cycle, particularly at the G₂/M checkpoint. It inhibits cell cycle progression by phosphorylating and inactivating CDK1 (Cyclin-Dependent Kinase 1) at Tyr15, thereby preventing premature entry into mitosis and allowing time for DNA repair.Originally identified in fission yeast, WEE1 is highly conserved in mammals and plays a key role in maintaining genomic stability. Dysregulation of WEE1 is linked to cancer progression, as its overexpression in tumors (e.g., ovarian, breast, pancreatic cancers) supports cancer cell survival by enabling DNA damage tolerance. This dependency makes WEE1 a promising therapeutic target, especially in p53-mutant cancers where inhibiting WEE1 induces synthetic lethality by forcing cells with unrepaired DNA into catastrophic mitosis.
Product Specifications
Background
Specifications
Accession Number
P30291-1
Expression Region
Met 215 - Tyr 646
Host
Insect Cells
Target
WEE1
Conjugation
Unconjugated
Tag
N-10xHis
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Purity
80%
Format
Liquid
Buffer
50 mM Tris, 300 mM NaCl, pH7.5
Additives
Glycerol
Molecular Weight
51.1 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
1mg*1
Host or Source
InsectCells
Species
Human
Protein ID
P30291-1
Preservative
Glycerol
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