Human CXCR2 Protein, Flag, His Tag (Detergent)
Human CXCR2 Protein, Flag, His Tag (CX2-H55D3) is expressed from Baculovirus-Insect cells. It contains AA Glu 2 - Ser 344 (Accession # P25025) .
Product Specifications
Background
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8) . It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Specifications
This protein carries flag tag at the N-terminus and polyhistidine tag at the C-terminus. The protein has a calculated MW of 43.0 kDa.
Accession Number
P25025
Expression Region
Glu 2 - Ser 344
Host
Insect Cells
Target
CXCR2
Conjugation
Unconjugated
Tag
N-Flag & C-10xHis
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Purity
90%
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, DDM, pH7.5, CHS
Additives
Glycerol
Molecular Weight
43.0 kDa
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CX2-H55D3.pdf
Species
Human
Curated Selection
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