Human BAFF & APRIL Heterotrimer Protein, His Tag (MALS verified)

BAFF and APRIL are two members of the TNF superfamily that are secreted by activated myeloid cells and have costimulatory activity on B cells. BAFF/APRIL signaling regulates a diverse range of biological processes, including cell differentiation, proliferation, survival, and effector functions. Dysregulation of the BAFF/APRIL system has been linked to several inflammatory conditions, specifically autoimmune diseases. Elevated levels of BAFF and APRIL have been reported in autoimmune SLE patients. Both BAFF and APRIL have been described as homotrimeric molecules, a feature common to members of the TNF superfamily. But APRIL and BAFF can form active heterotrimer molecules when co-expressed, and circulating heterotrimer exists in serum samples of patients with systemic immune rheumatic diseases. These findings increase the possibility that the active BAFF/APRIL heterotrimer may play a role in rheumatic diseases and other autoimmune diseases.

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 50 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.