Human Granzyme B Protein, Tag Free (active enzyme)
Human Granzyme B Protein, Tag Free (GZB-H5213) is expressed from human 293 cells (HEK293) . It contains AA Ile 21 - Tyr 247 (Accession # P10144) .
Product Specifications
Background
Granzyme B (GZMB) is a cytosolic protease abundant in cytotoxic T-cells and natural killer cells, pivotal for immune defense. Delivered into target cells, GZMB activates caspase-independent pyroptosis by cleaving gasdermin-E (GSDME) . This triggers pyroptosis, leading to target cell death. GZMB exhibits substrate specificity for aspartate residue cleavage and contributes to an activation cascade of caspases, impacting apoptosis execution. Involved in bacterial infection response, GZMB cleaves and activates caspase-7, promoting plasma membrane repair. Its multifaceted activities underscore its crucial role in immune responses and cellular defense.
Specifications
This protein carries no "tag". The protein has a calculated MW of 25.5 kDa . The protein migrates as 34-37 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P10144
Expression Region
Ile 21 - Tyr 247
Host
HEK293
Target
Granzyme B
Conjugation
Unconjugated
Tag
Native
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Liquid
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
25.5 kDa
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
20ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/GZB-H5213.pdf
Species
Human
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
