Kaurenoic acid

Kaurenoic acid is a diterpene derived from Sphagneticola trilobata. Kaurenoic acid has antibacterial, anti-inflammatory, anticonvulsant, analgesic, and aortic vasodilating effects[1][2][3][4].

Product Specifications

CAS Number

[6730-83-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Potassium Channel

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kaurenoic-acid.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]1(C(O)=O)CCC[C@@]2(C)[C@@]3([H])[C@@]4(CC([C@H](CC3)C4)=C)CC[C@]12[H]

Molecular Formula

C20H30O2

Molecular Weight

302.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Mizokami SS, et al. Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. J Nat Prod. 2012 May 25;75 (5) :896-904.|[2]Carlos R Tirapelli, et al. Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta. Eur J Pharmacol. 2004 May 25;492 (2-3) :233-41.|[3]Sergio M Borghi, et al. The diterpene from Sphagneticola trilobata (L.) Pruski, kaurenoic acid, reduces lipopolysaccharide-induced peritonitis and pain in mice. J Ethnopharmacol. 2021 Jun 12:273:113980. |[4]Theophine C Okoye, et al. Anticonvulsant effect of kaurenoic acid isolated from the root bark of Annona senegalensis. Pharmacol Biochem Behav. 2013 Aug:109:38-43.