PD-118057
PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability[1][2].
Product Specifications
CAS Number
313674-97-4
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H413
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pd-118057.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=CC=C1NC2=CC=C(CCC3=CC=C(Cl)C(Cl)=C3)C=C2
Molecular Formula
C21H17Cl2NO2
Molecular Weight
386.27
Precautions
H315, H319, H335, H413
References & Citations
[1]Mao H, et al. Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin. PLoS One. 2013 Jun 19;8 (6) :e65481.|[2]Yeung SY, et al. Pharmacological and biophysical isolation of K+ currents encoded by ether-à-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am J Physiol Cell Physiol. 2007 Jan;292 (1) :C468-76. |[3]Meng J, et al. Effect of PD-118057attenuates hypokalaemia or drug-induced prolongation of action potential duration in guinea pig ventricular myocytes. 2014,29 (05) :536-538.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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