Gum arabic

Gum Arabic is an orally active complex branched polysaccharide. Gum Arabic can be isolated from the Acacia senegal tree. Gum Arabic upregulates the expression of maturation markers (CD86, CD40, and CD54), promotes ERK1/2 phosphorylation, and inhibits Apoptosis. Gum Arabic exhibits antimalarial effects against Plasmodium berghei ANKA. Gum Arabic exhibits hepatoprotective, renal, and cardiovascular protective activities. Gum Arabic improves obesity. Gum Arabic is commonly used as a stabilizer and thickener. Gum Arabic can be used in the research of brain tumor imaging[1][2][3][4][5][6][7][8][9][10].

Product Specifications

CAS Number

[9000-01-5]

Product Name Alternative

Arabic gum

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Apoptosis; Others; Parasite; PERK; Transmembrane Glycoprotein

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Others

Field of Research

Cancer; Infection; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gum-arabic.html

Solubility

H2O : ≥ 50 mg/mL

Smiles

[Gumarabic]

Molecular Weight

200-300

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice. Pharmacological Research. Volume 48, Issue 6, December 2003, Pages 631-635.|[2]Ali BH , et al. Biological effects of gum arabic: a review of some recent research. Food Chem Toxicol. 2009 Jan;47 (1) :1-8.|[3]Gilerovitch HG, et al. The use of electron microscopic immunocytochemistry with silver-enhanced 1.4-nm gold particles to localize GAD in the cerebellar nuclei. J Histochem Cytochem. 1995 Mar;43 (3) :337-43.|[4]Anderson D M W, et al. The safety of gum arabic as a food additive and its energy value as an ingredient: a brief review. Journal of Human Nutrition and Dietetics, 1989, 2 (3) : 137-144.|[5]Ballal A, et al. Anti-malarial effect of gum arabic. Malar J. 2011 May 20;10:139. |[6]Xuan NT, et al. Stimulation of mouse dendritic cells by Gum Arabic. Cell Physiol Biochem. 2010;25 (6) :641-8.|[7]Zhang L, et al. Gum arabic-coated magnetic nanoparticles for potential application in simultaneous magnetic targeting and tumor imaging. AAPS J. 2009 Dec;11 (4) :693-9. |[8]Ali BH, et al. Gum arabic reduces inflammation, oxidative, and nitrosative stress in the gastrointestinal tract of mice with chronic kidney disease. Naunyn Schmiedebergs Arch Pharmacol. 2020 Aug;393 (8) :1427-1436. |[9]Nemmar A, et al. Gum Arabic Ameliorates Impaired Coagulation and Cardiotoxicity Induced by Water-Pipe Smoke Exposure in Mice. Front Physiol. 2019 Feb 25;10:53. |[10]Ahmed A A, et al. Gum arabic suppressed diet-induced obesity by alteration the expression of mRNA levels of genes involved in lipid metabolism in mouse liver. Bioactive carbohydrates and dietary fibre, 2016, 7 (1) : 15-20.