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LM2I

LM2I is a derivative of Spinosyn A (SPA) . LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway[1].

Product Specifications

CAS Number

[2055494-50-1]

UNSPSC

12352005

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lm2i.html

Purity

99.78

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=C[C@]2([H])[C@](C=C[C@@]3([H])[C@@]2([H])C[C@H](O[C@@H]4O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]4OC)C3)([H])[C@]1([H])C5)[C@H](C)[C@@H](O[C@@H]6O[C@H](C)[C@@H](N(CC(O)CN7CCNCC7)C)CC6)CCC[C@H](CC)OC5=O

Molecular Formula

C47H77N3O11

Molecular Weight

860.13

References & Citations

[1]Peng K, et al. Spinosyn A and Its Derivative Inhibit Colorectal Cancer Cell Growth via the EGFR Pathway. J Nat Prod. 2023 Sep 8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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