SKF89976A (hydrochloride)

SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

Product Specifications

CAS Number

[85375-15-1]

Product Name Alternative

D, l-SKF89976A hydrochloride

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SKF89976A-hydrochloride.html

Purity

98.73

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

O=C(C1CN(CC/C=C(C2=CC=CC=C2)/C3=CC=CC=C3)CCC1)O.[H]Cl

Molecular Formula

C22H26ClNO2

Molecular Weight

371.90

Precautions

H315, H319, H335

References & Citations

[1]Jinzenji A, et al. Antiallodynic action of 1- (3- (9H-Carbazol-9-yl) -1-propyl) -4- (2-methyoxyphenyl) -4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor. J Pharmacol Sci. 2014;125 (2) :217-26.|[2]Kreitzer MA, et al. Glutamate modulation of GABA transport in retinal horizontal cells of the skate. J Physiol. 2003 Feb 1;546 (Pt 3) :717-31.|[3]Barakat L, et al. GAT-1 and reversible GABA transport in Bergmann glia in slices. J Neurophysiol. 2002 Sep;88 (3) :1407-19.