Leukotriene A4 methyl ester
Leukotriene A4 methyl ester (LTA4 methyl ester) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
Product Specifications
CAS Number
[73466-12-3]
Product Name Alternative
LTA4 methyl ester
UNSPSC
12352005
Hazard Statement
H225-H304-H315-H319-H336-H361-H373-H411
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/leukotriene-a4-methyl-ester.html
Smiles
O=C(OC)CCC[C@@H]1O[C@H]1/C=C/C=C/C=C\C/C=C\CCCCC
Molecular Formula
C21H32O3
Molecular Weight
332.48
Precautions
References & Citations
[1]Samuelsson, et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237 (4819), 1171-1176 (1987) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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