Sudoxicam

Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity[1][2][3].

Product Specifications

CAS Number

[34042-85-8]

UNSPSC

12352005

Hazard Statement

H301

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sudoxicam.html

Purity

99.96

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

OC(C1=CC=CC=C12)=C(C(NC3=NC=CS3)=O)N(C)S2(=O)=O

Molecular Formula

C13H11N3O4S2

Molecular Weight

337.37

Precautions

H301

References & Citations

[1]Obach RS, et al. In vitro metabolism and covalent binding of enol-carboxamide derivatives and anti-inflammatory agents sudoxicam and meloxicam: insights into the hepatotoxicity of sudoxicam. Chem Res Toxicol. 2008 Sep;21 (9) :1890-9.|[2] Wiseman EH, et al. Anti-inflammatory and pharmacokinetic properties of sudoxicam N- (2-thiazolyl) -4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide. Biochem Pharmacol. 1972 Sep 1;21 (17) :2323-34.|[3]Zhi-Yi Zhang. Sudoxicam. Handbook of Metabolic Pathways of Xenobiotics. September 2014.