(Rac) -PF-998425

(Rac) -PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist. (Rac) -PF-998425 has IC50 values of 26 and 90 nM in the AR binding and cellular assays, respectively. (Rac) -PF-998425 has the potential for the research of the androgenetic alopecia[1].

Product Specifications

CAS Number

[1076225-26-7]

UNSPSC

12352005

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/rac-pf-998425.html

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1C(CCCC1)C2=CC(C(F)(F)F)=C(C=C2)C#N

Molecular Formula

C14H14F3NO

Molecular Weight

269.26

References & Citations

[1]Li JJ, et al. Rational design and synthesis of 4- ((1R,2R) -2-hydroxycyclohexyl) -2 (trifluoromethyl) benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008;51 (21) :7010-7014.