(Rac)-PF-998425
Product Specifications
UNSPSC Description
(Rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist. (Rac)-PF-998425 has IC50 values of 26 and 90 nM in the AR binding and cellular assays, respectively. (Rac)-PF-998425 has the potential for the research of the androgenetic alopecia[1].
Target Antigen
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/rac-pf-998425.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1C(CCCC1)C2=CC(C(F)(F)F)=C(C=C2)C#N
Molecular Weight
269.26
References & Citations
[1]Li JJ, et al. Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008;51(21):7010-7014.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14250A/Rac-PF-998425-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14250A/Rac-PF-998425-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1076225-26-7
Available Sizes
Curated Selection
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