(Rac) -PF-998425
(Rac) -PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist. (Rac) -PF-998425 has IC50 values of 26 and 90 nM in the AR binding and cellular assays, respectively. (Rac) -PF-998425 has the potential for the research of the androgenetic alopecia[1].
Product Specifications
CAS Number
[1076225-26-7]
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/rac-pf-998425.html
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1C(CCCC1)C2=CC(C(F)(F)F)=C(C=C2)C#N
Molecular Formula
C14H14F3NO
Molecular Weight
269.26
References & Citations
[1]Li JJ, et al. Rational design and synthesis of 4- ((1R,2R) -2-hydroxycyclohexyl) -2 (trifluoromethyl) benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008;51 (21) :7010-7014.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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