4-MUNANA

4-MUNANA is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU) . By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses[1][2].

Product Specifications

CAS Number

[76204-02-9]

UNSPSC

12171500

Hazard Statement

H315, H319, H335

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-munana.html

Purity

98.08

Solubility

H2O : 233.33 mg/mL (ultrasonic)

Smiles

O=C(O[Na])[C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)OC2=CC=C(C(C)=CC(O3)=O)C3=C2

Molecular Formula

C21H24NNaO11

Molecular Weight

489.41

Precautions

H315, H319, H335

References & Citations

[1]Xu R, et al. Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic. J Virol. 2012 Sep;86 (17) :9221-32.|[2]Ma F, et al. Fluorescence paper sensor meets magnetic affinity chromatography: discovering potent neuraminidase inhibitors in herbal medicines. Anal Bioanal Chem. 2025 Apr;417 (9) :1819-1832.