FAK ligand-Linker Conjugate 1
FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP) . FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation[1].
Product Specifications
CAS Number
[2307461-45-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-ligand-linker-conjugate-1.html
Concentration
10mM
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCOCCOC1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=CC=CC(N(C)S(=O)(C)=O)=C3)=N2)C=C1
Molecular Formula
C25H28F3N5O6S
Molecular Weight
583.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140 (49) :17019-17026.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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