JNJ-54175446
Product Specifications
Product Name Alternative
MC 903 (Standard); Calcipotriene (Standard),1,25-Dihydroxyvitamin D3
UNSPSC Description
JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.
Target Antigen
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/JNJ-54175446.html
Purity
99.30
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
ClC1=C(C=CC=C1C(N2CCC3=C(N=NN3C4=NC=C(F)C=N4)[C@H]2C)=O)C(F)(F)F
Molecular Weight
440.78
References & Citations
[1]Letavic MA, et al. 4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate. Send to
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117508/JNJ-54175446-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117508/JNJ-54175446-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1627902-21-9
Available Sizes
Curated Selection
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