JNJ-54175446

JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.

Product Specifications

CAS Number

[1627902-21-9]

Product Name Alternative

MC 903 (Standard); Calcipotriene (Standard),1,25-Dihydroxyvitamin D3

UNSPSC

12352005

Hazard Statement

H302

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/JNJ-54175446.html

Concentration

10mM

Purity

99.30

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

ClC1=C(C=CC=C1C(N2CCC3=C(N=NN3C4=NC=C(F)C=N4)[C@H]2C)=O)C(F)(F)F

Molecular Formula

C18H13ClF4N6O

Molecular Weight

440.78

Precautions

H302

References & Citations

[1]Letavic MA, et al. 4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate. Send to