JNJ-54175446
JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.
Product Specifications
CAS Number
[1627902-21-9]
Product Name Alternative
MC 903 (Standard); Calcipotriene (Standard),1,25-Dihydroxyvitamin D3
UNSPSC
12352005
Hazard Statement
H302
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/JNJ-54175446.html
Concentration
10mM
Purity
99.30
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
ClC1=C(C=CC=C1C(N2CCC3=C(N=NN3C4=NC=C(F)C=N4)[C@H]2C)=O)C(F)(F)F
Molecular Formula
C18H13ClF4N6O
Molecular Weight
440.78
Precautions
H302
References & Citations
[1]Letavic MA, et al. 4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate. Send to
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
P2X7 Receptor
Available Sizes
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