Hippuryl-His-Leu-OH (hydrate)

Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) hydrate is a substrate for detecting the activity of angiotensin I converting enzyme. The His-Leu released by Hippuryl-His-Leu-OH hydrate can react with o-phtbaldialdehyde or Fluorescamine (HY-D0715) for fluorescence detection[1][2][3].

Product Specifications

CAS Number

[207386-83-2]

Product Name Alternative

N-Benzoyl-Gly-His-Leu (hydrate)

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives; Angiotensin-converting Enzyme (ACE)

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/n-benzoyl-gly-his-leu-hydrate.html

Purity

99.65

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 14.29 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(O)=O)CC(C)C)[C@@H](NC(CNC(C1=CC=CC=C1)=O)=O)CC2=CN=CN2.[x].O

Molecular Formula

C21H27N5O5.xH2O

Molecular Weight

429.47 (free acid)

Precautions

H302, H315, H319, H335

References & Citations

[1]Nishimura K, et al. Purification of angiotensin I-converting enzyme from human lung. Biochim Biophys Acta. 1977 Aug 11;483 (2) :398-408. |[2]Santos RA, et al. An improved fluorometric assay of rat serum and plasma converting enzyme. Hypertension. 1985 Mar-Apr;7 (2) :244-52. |[3]Horiuchi M, et al. Method for determination of angiotensin-converting enzyme activity in blood and tissue by high-performance liquid chromatography. J Chromatogr. 1982 Dec 10;233:123-30.