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Chloramphenicol succinate (sodium)

Chloramphenicol succinate sodium is a proagent of Chloramphenicol, with haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity. Chloramphenicol succinate acts as a prodrug, being converted to active chloramphenicol by esterases while it is circulating in the body[1][2][3].

Product Specifications

CAS Number

982-57-0

UNSPSC

12352005

Hazard Statement

H302, H351

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Infection

Assay Protocol

https://www.medchemexpress.com/chloramphenicol-succinate-sodium.html

Concentration

10mM

Purity

99

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(CCC(O[Na])=O)OC[C@H]([C@@H](C1=CC=C(C=C1)[N+]([O-])=O)O)NC(C(Cl)Cl)=O

Molecular Formula

C15H15Cl2N2NaO8

Molecular Weight

445.18

Precautions

H302, H351

References & Citations

[1]Ambrose PJ. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984 May-Jun;9 (3) :222-38.|[2]Ambekar CS, et al. Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Toxicol In Vitro. 2004 Aug;18 (4) :441-7.|[3]Turton JA, et al. Haemotoxicity of chloramphenicol succinate in the CD-1 mouse and Wistar Hanover rat. Hum Exp Toxicol. 1999 Sep;18 (9) :566-76.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Natural Products

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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