IDO1/TDO-IN-4

IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO) . IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders[1].

Product Specifications

CAS Number

[461424-21-5]

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ido1-tdo-in-4.html

Purity

99.74

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C12=CC=CC=C1NC3=C2C=CN=C3C4=CNC=N4

Molecular Formula

C14H10N4

Molecular Weight

234.26

References & Citations

[1]Yu Zhang, et al. B Discovery of 1- (Hetero) aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity. J Med Chem. 2022 Aug 7.