IDO1/TDO-IN-4
Product Specifications
UNSPSC Description
IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π?π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders[1].
Target Antigen
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ido1-tdo-in-4.html
Solubility
DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)|Methanol : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C12=CC=CC=C1NC3=C2C=CN=C3C4=CNC=N4
Molecular Weight
234.26
References & Citations
[1]Yu Zhang, et al. B Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity. J Med Chem. 2022 Aug 7.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151108/IDO1-TDO-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151108/IDO1-TDO-IN-4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
461424-21-5
Available Sizes
Curated Selection
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