E234G HYPE-IN-1

E234G HYPE-IN-1 (Compound I2.10) is an inhibitor of AMPylation directed by the Huntingtin-interacting protein E (HYPE), possessing low micromolar bioactivity, low cytotoxicity, and blood-brain barrier permeability. E234G HYPE-IN-1 can inhibit the AMPylation of B-cell immunoglobulin-binding protein (BiP), the primary substrate of HYPE. E234G HYPE-IN-1 is suitable for development as a HYPE-specific therapeutic agent for clinical conditions such as neurodegenerative diseases and diabetes[1].

Product Specifications

CAS Number

[1341007-95-1]

UNSPSC

12352005

Target

Amylases

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e234g-hype-in-1.html

Solubility

10 mM in DMSO

Smiles

C1(N2C=CN=C2)=NC=C(C3=NN=C(C4=COC=C4)O3)C=C1

Molecular Formula

C14H9N5O2

Molecular Weight

279.25

References & Citations

[1]Camara A, et al. Discovery and validation of a novel inhibitor of HYPE-mediated AMPylation. Cell Stress Chaperones. Published online April 9, 2024.