E234G HYPE-IN-1
E234G HYPE-IN-1 (Compound I2.10) is an inhibitor of AMPylation directed by the Huntingtin-interacting protein E (HYPE), possessing low micromolar bioactivity, low cytotoxicity, and blood-brain barrier permeability. E234G HYPE-IN-1 can inhibit the AMPylation of B-cell immunoglobulin-binding protein (BiP), the primary substrate of HYPE. E234G HYPE-IN-1 is suitable for development as a HYPE-specific therapeutic agent for clinical conditions such as neurodegenerative diseases and diabetes[1].
Product Specifications
CAS Number
[1341007-95-1]
UNSPSC
12352005
Target
Amylases
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e234g-hype-in-1.html
Solubility
10 mM in DMSO
Smiles
C1(N2C=CN=C2)=NC=C(C3=NN=C(C4=COC=C4)O3)C=C1
Molecular Formula
C14H9N5O2
Molecular Weight
279.25
References & Citations
[1]Camara A, et al. Discovery and validation of a novel inhibitor of HYPE-mediated AMPylation. Cell Stress Chaperones. Published online April 9, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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