Exo-IWR-1

Exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1 (HY-12238) . IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway[1][2].

Product Specifications

CAS Number

[1127442-87-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/exo-iwr-1.html

Purity

98.75

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1C(C=C2)=CC=C2C(NC3=CC=CC4=C3N=CC=C4)=O)[C@@]5([H])[C@](C1=O)([H])[C@H]6C[C@@H]5C=C6

Molecular Formula

C25H19N3O3

Molecular Weight

409.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Brooke Hamion, et al. Genome-wide RNA Interference Screen Identifies Novel Drug Targets for Rift Valley Fever Virus That Minimi the Potential for Drug Resistance.|[2]Brooke Harmon, et al. A Genome-Wide RNA Interference Screen Identifies a Role for Wnt/β-Catenin Signaling during Rift Valley Fever Virus Infection. J Virol. 2016 Jul 27;90 (16) :7084-7097.