Diethylcarbamazine (citrate)

Diethylcarbamazine citrate is an orally active anthropoidal compound. Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism of filaria microfilaria. Diethylcarbamazine citrate has anti-inflammatory and antiparasitic activity[1][2][3].

Product Specifications

CAS Number

[1642-54-2]

UNSPSC

12352005

Hazard Statement

H302, H330

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Diethylcarbamazine-citrate.html

Concentration

10mM

Purity

98.01

Solubility

DMSO : ≥ 39 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(C)CC1)N(CC)CC.O=C(CC(C(O)=O)(O)CC(O)=O)O

Molecular Formula

C16H29N3O8

Molecular Weight

391.42

Precautions

H302, H330

References & Citations

[1]El-Shahawi GA, et al. Setaria equina: in vivo effect of diethylcarbamazine citrate on microfilariae in albino rats. Exp Parasitol. 2010 Dec;126 (4) :603-10.|[2]Abdul-Razek N, et al. Enhancement of Anti-allergic Effect of Diethylcarbamazine Citrate in Asthmatic Mouse Model: Testing of Anti-drug Antibodies and Quercetin. Iran J Allergy Asthma Immunol. 2020 Aug 25;19 (4) :373-385.|[3]Abdel-Latif M. Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. Int Immunopharmacol. 2015 Dec;29 (2) :607-612.