Peiminine

Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models[1][2][3][4][5][6].

[1]Guo H, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10.|[2]Chao X, et al. The effects and mechanism of peiminine-induced apoptosis in human hepatocellular carcinoma HepG2 cells [J]. PLoS One, 2019, 14(1): e0201864.|[3]Ranjbar Bushehri M, et al. Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model [J]. Inflammopharmacology, 2023: 1-9.|[4]Gu H, et al. Peiminine regulates bone-fat balance by canonical Wnt/β-catenin pathway in an ovariectomized rat mode [J]. Phytotherapy Research, 2023.|[5]Lim J M, et al. Effect of peiminine on DNCB-induced atopic dermatitis by inhibiting inflammatory cytokine expression in vivo and in vitro [J]. International immunopharmacology, 2018, 56: 135-142.|[6]Chen P, et al. Peiminine inhibits myocardial injury and fibrosis after myocardial infarction in rats by regulating mitogen-activated protein kinase pathway [J]. The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2022, 26(2): 87-94.|[7]Du B, et al. Peiminine attenuates acute lung injury induced by LPS through inhibiting lipid rafts formation [J]. Inflammation, 2020, 43: 1110-1119.