Peiminine

Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family) . Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models[1][2][3][4][5][6].

Product Specifications

CAS Number

[18059-10-4]

Product Name Alternative

Verticinone; Raddeanine

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Apoptosis; Autophagy; Bcl-2 Family; Caspase; ERK; NF-κB; p38 MAPK; PARP

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Peiminine.html

Purity

99.89

Solubility

DMSO : ≥ 100 mg/mL

Smiles

[H][C@]12[C@]3([H])CC([C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])C[C@]([H])1[C@]5([H])CN6C[C@@H](C)CC[C@]([H])6[C@@](C)(O)[C@]([H])5CC2)=O

Molecular Formula

C27H43NO3

Molecular Weight

429.64

Precautions

H302+H312+H332

References & Citations

[1]Guo H, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7 (4) :1103-10.|[2]Chao X, et al. The effects and mechanism of peiminine-induced apoptosis in human hepatocellular carcinoma HepG2 cells [J]. PLoS One, 2019, 14 (1) : e0201864.|[3]Ranjbar Bushehri M, et al. Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model [J]. Inflammopharmacology, 2023: 1-9.|[4]Gu H, et al. Peiminine regulates bone-fat balance by canonical Wnt/β-catenin pathway in an ovariectomized rat mode [J]. Phytotherapy Research, 2023.|[5]Lim J M, et al. Effect of peiminine on DNCB-induced atopic dermatitis by inhibiting inflammatory cytokine expression in vivo and in vitro [J]. International immunopharmacology, 2018, 56: 135-142.|[6]Chen P, et al. Peiminine inhibits myocardial injury and fibrosis after myocardial infarction in rats by regulating mitogen-activated protein kinase pathway [J]. The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2022, 26 (2) : 87-94.|[7]Du B, et al. Peiminine attenuates acute lung injury induced by LPS through inhibiting lipid rafts formation [J]. Inflammation, 2020, 43: 1110-1119.