Dexchlorpheniramine (maleate)

Dexchlorpheniramine maleate is an orally taken anti-histamine that has anti-inflammatory, anti-irritant, anti-allergic, and skin barrier effects. Dexchlorpheniramine maleate inhibits myocardial contraction in rats. Dexchlorpheniramine maleate can be used in studies of allergic rhinitis[1][2][3].

Product Specifications

CAS Number

[2438-32-6]

Product Name Alternative

S- (+) -Chlorpheniramine maleate salt

UNSPSC

12352005

Hazard Statement

H301

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Dexchlorpheniramine-maleate.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL

Smiles

O=C(O)/C=C\C(O)=O.CN(C)CC[C@H](C1=NC=CC=C1)C2=CC=C(Cl)C=C2

Molecular Formula

C20H23ClN2O4

Molecular Weight

390.86

Precautions

H301

References & Citations

[1]Gustavo Facchini, et al. Ultraviolet A photosensitivity profile of dexchlorpheniramine maleate and promethazine-based creams: Anti-inflammatory, antihistaminic, and skin barrier protection properties. J Cosmet Dermatol. 2017 Dec;16 (4) :e59-e67.|[2]Gabriel Curbelo-Gonzalez, et al. Contractile and electrical activities of dexchlorpheniramine on rat hearts.Medcrave. Volume 7 Issue 5 – 2018|[3]E P Munch, et al. A comparative study of dexchlorpheniramine maleate sustained release tablets and budesonide nasal spray in seasonal allergic rhinitis. Allergy. 1983 Oct;38 (7) :517-24.