Phototrexate
Phototrexate is a photoswitchable inhibitor of the human dihydrofolate reductase (DHFR) . Phototrexate has antifolate and antiproliferative properties, which can be used for the research of cancer[1].
Product Specifications
CAS Number
[2268033-83-4]
Product Name Alternative
(E) -azoMTX
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phototrexate.html
Purity
96.70
Solubility
10 mM in DMSO
Smiles
NC1=NC(N)=NC2=C1C=C(/N=N/C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C2
Molecular Formula
C20H19N7O5
Molecular Weight
437.41
References & Citations
[1]Matera C, et al. Photoswitchable Antimetabolite for Targeted Photoactivated Chemotherapy. J Am Chem Soc. 2018 Nov 21;140 (46) :15764-15773.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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