(Z) -FeCP-oxindole

(Z) -FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z) -FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z) -FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].

Product Specifications

CAS Number

[1137967-28-2]

UNSPSC

12352300

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-fecp-oxindole.html

Purity

99.62

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1/C(C2=CC=CC=C2N1)=C/[C-]34[Fe+2]56789%10%11([CH-]%12[CH]8=[CH]9[CH]%10=[CH]%11%12)[CH]3=[CH]5[CH]6=[CH]74

Molecular Formula

C19H15FeNO

Molecular Weight

329.17

References & Citations

[1]John Spencer, et al. Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics. 2011 Jun;3 (6) :600-8.