(Z) -FeCP-oxindole
(Z) -FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z) -FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z) -FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].
Product Specifications
CAS Number
[1137967-28-2]
UNSPSC
12352300
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-fecp-oxindole.html
Purity
99.62
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1/C(C2=CC=CC=C2N1)=C/[C-]34[Fe+2]56789%10%11([CH-]%12[CH]8=[CH]9[CH]%10=[CH]%11%12)[CH]3=[CH]5[CH]6=[CH]74
Molecular Formula
C19H15FeNO
Molecular Weight
329.17
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR1/Flt-1; VEGFR2/KDR/Flk-1
Available Sizes
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