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Chlorpheniramine

Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research[1][2].

Product Specifications

CAS Number

[132-22-9]

Product Name Alternative

Chlorphenamine

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/chlorpheniramine.html

Purity

99.86

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=CC=CC=N2

Molecular Formula

C16H19ClN2

Molecular Weight

274.79

Precautions

H315, H319, H320

References & Citations

[1]Jiwon Kim, etal. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128.|[2]Kyung-Jin Jung, etal. Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine. Arch Pharm Res. 2012 Dec;35 (12) :2183-9.|[3]Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471 (3) : p. 223-8.|[4]Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51 (11) : p. 4133-40.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-B0286/Chlorpheniramine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-B0286/Chlorpheniramine-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

J Inflamm Res. 2025 Jun 17:18:7907-7919.|Neuropharmacology. 2025 Nov 1:278:110593.|Chemosphere. 2019 Jun:225:378-387.|J Pharm Sci. 2019 Sep;108 (9) :2895-2904.

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