Chlorpheniramine
Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research[1][2].
Product Specifications
CAS Number
132-22-9
Product Name Alternative
Chlorphenamine
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chlorpheniramine.html
Purity
99.86
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CN(C)CCC(C1=CC=C(Cl)C=C1)C2=CC=CC=N2
Molecular Formula
C16H19ClN2
Molecular Weight
274.79
Precautions
H315, H319, H320
References & Citations
[1]Jiwon Kim, etal. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128.|[2]Kyung-Jin Jung, etal. Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine. Arch Pharm Res. 2012 Dec;35 (12) :2183-9.|[3]Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471 (3) : p. 223-8.|[4]Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51 (11) : p. 4133-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
J Inflamm Res. 2025 Jun 17:18:7907-7919.|Neuropharmacology. 2025 Nov 1:278:110593.|Chemosphere. 2019 Jun:225:378-387.|J Pharm Sci. 2019 Sep;108 (9) :2895-2904.
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