(S, R, S) -AHPC-propargyl

(S, R, S) -AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs[1]. (S, R, S) -AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2098799-78-9]

Product Name Alternative

VH032-propargyl; VHL ligand 7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-propargyl.html

Concentration

10mM

Purity

99.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(COCC#C)=O)C(C)(C)C)=O)=O)C=C2

Molecular Formula

C27H34N4O5S

Molecular Weight

526.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61 (2) :453-461.