(S,R,S)-AHPC-propargyl
Product Specifications
Product Name Alternative
VH032-propargyl; VHL ligand 7
UNSPSC Description
(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs[1]. (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-propargyl.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(COCC#C)=O)C(C)(C)C)=O)=O)C=C2
Molecular Weight
526.65
References & Citations
[1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126456/S-R-S-AHPC-propargyl-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126456/S-R-S-AHPC-propargyl-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2098799-78-9
Available Sizes
Curated Selection
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