Keracyanin (chloride)

Keracyanin chloride inhibits NF-κB/FAK/MAPK signaling pathway. Keracyanin chloride exhibits antioxidant, anti-inflammatory and hypoglycemic effects, and is orally active[1][2][3][4][5].

Product Specifications

CAS Number

[18719-76-1]

Product Name Alternative

Cyanidin 3-rutinoside (chloride) ; Cyanidin 3-O-rutinoside (chloride) ; Sambucin (chloride)

UNSPSC

12352005

Hazard Statement

H302

Target

ERK; FAK; JNK; NF-κB; p38 MAPK; PPAR; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/keracyanin-chloride.html

Purity

99.90

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC1=C2C([O+]=C(C3=CC(O)=C(O)C=C3)C(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO[C@H]5[C@@H]([C@@H]([C@@H](O)[C@H](C)O5)O)O)=C2)=CC(O)=C1.[Cl-]

Molecular Formula

C27H31ClO15

Molecular Weight

630.98

Precautions

H302

References & Citations

[1]Mazzaracchio P, et al. Interaction between gliadins and anthocyan derivatives. Food Chem. 2011 Dec 1;129 (3) :1100-7.|[2]Matsufuji H, et al. Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants. J Agric Food Chem. 2004 Sep 8;52 (18) :5759-63.|[3]Santamarina AB , et al., Anti-inflammatory effects of oleic acid and the anthocyanin keracyanin alone and in combination: effects on monocyte and macrophage responses and the NF-κB pathway. Food Funct. 2021 Sep 7;12 (17) :7909-7922.|[4]Lee H Y, et al. Cherry fruit anthocyanins cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside protect against blue light-induced cytotoxicity in HaCaT cells[J]. Applied Biological Chemistry, 2023, 66 (1) : 3.|[5]Adisakwattana S, et al., Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase. J Clin Biochem Nutr. 2011 Jul;49 (1) :36-41.