MS33
MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].
Product Specifications
CAS Number
2407449-11-8
UNSPSC
12352005
Target
Histone Methyltransferase; PROTACs; WDR5
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms33.html
Solubility
10 mM in DMSO
Smiles
CN(CC1)CCN1C(C(NC(C2=CNC(C=C2C(F)(F)F)=O)=O)=C3)=CC=C3C4=CC(CN5CCN(CCNC(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N6C[C@H](O)C[C@H]6C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)=O)CC5)=CC=C4
Molecular Formula
C64H84F3N11O7S
Molecular Weight
1208.48
References & Citations
[1]Yu X, et, al. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med. 2021 Sep 29;13 (613) :eabj1578.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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