7-Hydroxyflavanone
7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC50 of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-) estrogenic effects, and modula
Product Specifications
CAS Number
[6515-36-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cytochrome P450
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/7-hydroxyflavanone.html
Purity
99.59
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1CC(C2=CC=CC=C2)OC3=C1C=CC(O)=C3
Molecular Formula
C15H12O3
Molecular Weight
240.25
Precautions
H315, H319, H335
References & Citations
[1]Sanderson JT, et al. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov;82 (1) :70-9. |[2]J Thomas Sanderson, et al. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov;82 (1) :70-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Aromatase/CYP19A1
Available Sizes
Curated Selection
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